Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent heterogeneous disease associated with ovulatory dysfunction and hyperandrogenemia. Recent data support a critical role of neuroendocrine dysfunction and metabolic disturbances in the pathophysiology of the syndrome, including hyperleptinaemia. Accumulating evidence suggests that circadian desynchrony is linked to obesity and metabolic syndrome (MetS). Both prevalence and incidence of the metabolic syndrome is v...

Objective: To compare kisspeptin levels between different phenotypes of PCOS and to analyze the correlation between kisspeptin and PCOS-related hormonal and metabolic disturbances.Patients and methods: The study included 87 women with PCOS, and a control group of 27 clinically healthy women, corresponding in age and BMI to the patients with PCOS. Circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), sex-hor...